These data both confirm and extend prior knowledge about the base preferences conferred by individual residues within the C2H2-ZF domain 1, motivating us to develop an improved recognition code model.

Toronto scientists have discovered that the largest group of human proteins, which work as genome gatekeepers to control gene activity, are even more diverse in their roles than previously thought.

Researchers at the University of Toronto have shown that an important class of DNA-binding factors can also bind to RNA, regulating gene expression through various mechanisms. The study significantly ...