Nature

Identification and characterization of multiple splice forms of the human interleukin-23 receptor α chain in mitogen-activated leukocytes

The human IL23R gene is located on chromosome 1p32.1–p31.2, 150 kb telomeric of the adjacent gene, IL12Rβ2. The ‘native form’ of human IL23R mRNA is 2.8 kb long and comprises 11 exons (NM_144701). The ...
Nature

Hypercholesterolemia associated with splice-junction variation of inter-α-trypsin inhibitor heavy chain 4 (ITIH4) gene

Accumulating evidences derived from clinical, epidemiological, and experimental studies suggest that lipid and lipoprotein concentrations in plasma reflect the influence of complex genetic loci, at ...