Treatment with oral semaglutide (Rybelsus) significantly improved motivation measures in patients with major depressive ...

One of the key features of depression is the lack of motivation to do things that you know you should really do. For example, you may think that you don't have the motivation to exercise, or spend ...

McCall weighs in on lack of motivation in depression, and when it may start to come back once you're on the right treatment.

Something changed when Sasha W. noticed the hot pink running shoes sitting in the corner of her bedroom. She was 27 at the time and struggling with the worst depressive valley of her life. As she lay ...

April 29, 2026 expert reaction to RCT which looks at semaglutide and motivation in depression . A randomised controlled trial published in JAMA Psychiatry looks at semaglutide use ...

Depression can make getting out of bed in the morning difficult and powering through a work day feel near-impossible. <a href="https://www.nimh.nih.gov/health ...

For many people, depression does not feel like dramatic despair. It feels like heaviness; like waking up already exhausted by a day that hasn't yet begun. “And depression doesn’t just affect mood, it ...

New research shows that individuals who have recovered from depression are generally less willing to exert effort to pursue potential rewards compared to those who have never experienced depression, ...

People struggling with symptoms of depression are less likely to perceive themselves as active initiators of their activities ...

Depression is a mental health condition that can show up as visible sadness and exhaustion, but a lot of times, it can also ...

Past studies on smoking cessation excluded people with depression to simplify the results. But common symptoms of depression can also overlap with nicotine withdrawal symptoms, which may make it ...