August Weismann's germ plasm theory of the late 19th century posited that only germ cells, e.g., sperm and egg cells in ...
Hereditary breast cancer results from inherited mutations, primarily in BRCA1 and BRCA2, increasing lifetime cancer risk. Additional genes like TP53, PTEN, PALB2, CHEK2, and ATM also contribute to ...
The prevalence and spectrum of predisposing mutations among children and adolescents with cancer are largely unknown. Knowledge of such mutations may improve the understanding of tumorigenesis, direct ...
From 7% to nearly 9% of patients with advanced cancer were found to harbor a germline variant with targeted therapeutic actionability in the first study of its kind. The study involved 11,974 patients ...
Young breast cancer survivors without a specific genetic mutation have a lower risk of developing second primary breast cancer within 10 years of diagnosis. Young patients that survived breast cancer ...
Real-world performance of a multi-cancer early detection test based on integrative analysis of cell-free DNA whole-methylome sequencing. This is an ASCO Meeting Abstract from the 2023 ASCO Annual ...
The association between Gleason grade group, PSA levels, and prostatectomy outcomes for the optimized treatment of prostate cancer patients. Multivariable logistic regression model assessing ...
Most cancer genome studies have focused on mutations in the tumor itself and how such gene variants allow a tumor to grow unchecked. A new study takes a deep dive into inherited cancer mutations ...
A man sits outside and holds a slim menthol cigarette between his fingers. Close-up with focus on the cigarette. The study provided a comprehensive examination of how lifestyle and environmental ...
Carbone called BAP1 a “paradox” because of its seeming ability to both promote and slow cancer, depending on the ...
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