When analyzing these pairs, researchers identified patterns between the extracellular and intracellular signals. They then trained a deep learning model to predict what the intracellular signals ...

More than 1,000 bitter-tasting compounds are recognized by a repertoire of 26 membrane proteins called the type-2 taste receptors (TAS2Rs), also known as the bitter taste receptors 1, 2. Our ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...

1 By the late 1960s, researchers had become aware that this somewhat obscure class of lipids had the remarkable ability to act like an extracellular signaling molecule. 2 Two prominent forms typify ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Bitter taste receptors are not only expressed in oral cavity cells but also in the gastrointestinal lining. To understand the diverse functions of these receptors, understanding the structure is ...

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