In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

KRAS is the most frequently mutated oncogene across all human cancers. Although different KRAS mutations have long been thought to exert the same cancer-driving effects, a new study led by UT ...

Inheriting a mutation in BRCA1 or BRCA2 puts you at higher risk of breast, prostate, ovarian and pancreatic cancer. Genetic ...

Whole-exome sequencing of liver transplant patients with hepatocellular carcinoma has identified a 13-gene mutation signature ...

KRAS mutations lead to excessive cell growth due to alterations in the KRAS gene. They are present in a significant percentage of non-small cell lung cancers (NSCLC). Diagnosis involves testing ...

A study led by the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), working in collaboration with an international research team, has identified a new molecular mechanism ...

A study demonstrates that the 'previous state' of blood stem cells plays a decisive role in the subtype of leukemia that develops. The new technique, called STRACK, allows monitoring of the evolution ...

A groundbreaking study published in PNAS by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not randomly but more frequently where it ...

Researchers at the Institute for Bioengineering of Catalonia (IBEC) have produced a mutational map showing how mutations in amylin—a hormone that plays a key role in glucose regulation—affect its ...

In one of the more sobering patterns in oncology, patients with hypopharyngeal squamous cell carcinoma often respond ...