The regulation of neuronal excitability and the maintenance of an appropriate balance between excitation and inhibition are central to brain function. Inhibitory synaptic transmission, predominantly ...

They used synapses from the fruit fly drosophila, which compares remarkably closely to synapses in humans. The results showed that two variations of a protein called Unc13 work separately to regulate ...

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...

A new study by Pitt researchers challenges a decades-old assumption in neuroscience by showing that the brain uses distinct transmission sites—not a shared site—to achieve different types of ...

For decades, neuroscientists have debated whether synaptic vesicles “kiss-and-run” or do an irreversible “full collapse” when releasing neurotransmitters. Now, a team in China has frozen that moment ...

Axons, the fundamental output structures of neurons, play a pivotal role in transmitting electrical signals over long distances without attenuation in the nervous system. Beyond their classical role ...