Boltz builds frontier AI models and agents for computational drug discovery, from structure prediction to binding affinity and protein design. Used by 100K+ scientists across pharma, biotech, and academia.

Boltz is a family of models for biomolecular interaction prediction. Boltz-1 was the first fully open source model to approach AlphaFold3 accuracy.

Jun 6, 2025 · Today, we are excited to announce Boltz-2, a new open-source foundation model for predicting biomolecular interactions. The model is the follow-up to Boltz-1, a popular open-source …

Jun 6, 2025 · Step-by-step guides on how to run the Boltz-2 model locally and through Rowan's computational_chemistry platform.

Nov 19, 2024 · Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning …

Jan 8, 2026 · Boltz's open-source biomolecular foundation models (Boltz-2, BoltzGen) are very popular AI tools in the pharmaceutical industry for protein design, biomolecular structure prediction, and...

Built on top of Boltz’s state-of-the-art AI agents, the Boltz Lab enables structure-based small-molecule and protein design to any target. The agents are powered by the Boltz model ecosystem, frontier AI …

Jun 18, 2025 · Here, we present Boltz-2, a new structural biology foundation model that exhibits strong performance for both structure and affinity prediction.

Jun 16, 2025 · Discover Boltz-2, a breakthrough AI model that predicts binding affinities with near FEP accuracy and over 1,000 times the speed. Learn how its structural upgrades, integrated steering, and …

Jan 8, 2026 · Founded by three MIT researchers, Boltz began by building open-source models that let any scientist explore complex biomolecular interactions — without needing the budget of a large …