For nuclear-encoded genes, splicing occurs in the nucleus either during or immediately after transcription. For those eukaryotic genes that contain introns, splicing is usually needed to create an …

May 8, 2022 · RNA splicing is a form of RNA processing in which a newly made precursor messenger RNA (mRNA) is transformed into a mature RNA by removing the non-coding sequences termed introns.

Apr 24, 2026 · Technological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning, have substantially deepened our …

In splicing, some sections of the RNA transcript (introns) are removed, and the remaining sections (exons) are stuck back together. Some genes can be alternatively spliced, leading to the production …

Aug 27, 2025 · RNA splicing is a fundamental biological process that refines genetic instructions. It is a crucial step in converting DNA information into functional components.

In this review, we aim to make this mechanism understandable and provide several videos of the spliceosome in action to illustrate the intricate choreography of splicing.

May 31, 2024 · What is RNA splicing? In order for mRNA to be translated into a protein, RNA splicing removes the intervening, non-coding sections of genes (introns) from pre-mRNA and links the protein …

Nov 14, 2020 · In this review, we summarize the current principles of splicing regulation, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, …

While the process of RNA splicing relies on multiple layers of regulatory elements, many years of research have shown that RNA structure within pre-mRNAs can significantly impact splicing …

The splicing of messenger RNA is accomplished and catalyzed by a macro-molecule complex known as the spliceosome. The areas for ligation and cleavage are determined by the many sub-units of the …